(extremely vulgar, dismissal) To go to hell, to disappear, go away or to screw oneself.
I wish you'd just fuck off.
To annoy, irritate.
It really fucks me off when you do that.
To fritter; to fuck around.
To die or leave unexpectedly.
He fucked off.
Go away! Get lost!
Expression of disagreement or disbelief.
Fuck off! You are joking, aren't you?